Title : Heterozygosity in the glutathione synthesis gene Gclm increases sensitivity to diesel exhaust particulate induced lung inflammation in mice.

Pub. Date : 2011 Oct

PMID : 21967497






1 Functional Relationships(s)
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1 DISCUSSION AND CONCLUSION: This finding indicates that GSH synthesis can mediate DEP-induced lung inflammation and suggests that polymorphisms in Gclm may be an important factor in determining adverse health outcomes in humans following inhalation of PM2.5. Glutathione glutamate-cysteine ligase modifier subunit Homo sapiens