Pub. Date : 2011 Oct
PMID : 21965742
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Combination of resveratrol and antiandrogen flutamide has synergistic effect on androgen receptor inhibition in prostate cancer cells. | Resveratrol | androgen receptor | Homo sapiens |
| 2 | RESULTS: Treatment of LNCaP cells with resveratrol (1-100 muM) resulted in the inhibition of androgen-promoted growth, inhibition of AR transcriptional activity and decrease in the AR and prostate-specific antigen protein levels through degradation pathways. | Resveratrol | androgen receptor | Homo sapiens |
| 3 | RESULTS: Treatment of LNCaP cells with resveratrol (1-100 muM) resulted in the inhibition of androgen-promoted growth, inhibition of AR transcriptional activity and decrease in the AR and prostate-specific antigen protein levels through degradation pathways. | Resveratrol | androgen receptor | Homo sapiens |
| 4 | The combination of resveratrol with flutamide had a synergistic effect on down-regulation of AR. | Resveratrol | androgen receptor | Homo sapiens |
| 5 | CONCLUSION: Resveratrol works in concert with antiandrogen flutamide to reduce the amount and activity of AR, suggesting new therapeutic strategies for the treatment of PCa. | Resveratrol | androgen receptor | Homo sapiens |