Title : Comparison of in vitro drug sensitivity by inhibition of tritium release from [5-3H]-2'-deoxyuridine and a clonogenic assay.

Pub. Date : 1990 May-Jun

PMID : 2195987






1 Functional Relationships(s)
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1 The ITR highly overestimated the cytotoxicity of 5-fluoro-2"-deoxyuridine: the irreversible inhibition of thymidylate synthase by this nucleoside resulted in an ED50 value 100-fold lower than that observed with the clonogenic assay. Nucleosides thymidylate synthetase Homo sapiens