Title : Vascular contribution of adrenomedullin to microcirculatory improvement in experimental colitis.

Pub. Date : 2011 Nov 30

PMID : 21958875






2 Functional Relationships(s)
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1 TNBS instillation induced COX-2 and iNOS expressions in colon and small mesenteric arteries; AM treatment decreased COX-2 expression only in microvessels from rats with colitis. Trinitrobenzenesulfonic Acid prostaglandin-endoperoxide synthase 2 Rattus norvegicus
2 COX and NOS inhibitors altered the contractile ability of phenylephrine in small mesenteric arteries from TNBS rats, suggesting the involvement of COX-2 and iNOS derived factors in the deleterious effect of TNBS on vascular reactivity; AM administration was able to reduce such alteration. Trinitrobenzenesulfonic Acid prostaglandin-endoperoxide synthase 2 Rattus norvegicus