Title : Activation of group I mGlu receptors contributes to facilitation of NMDA receptor membrane current in spinal dorsal horn neurons after hind paw inflammation in rats.

Pub. Date : 2011 Nov 30

PMID : 21951968






1 Functional Relationships(s)
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1 The DHPG-produced facilitation of NMDA-induced current was blocked by intracellular dialysis of GDP-beta-S (1 mM), a G protein antagonist, and BAPTA (15 mM), an intracellular calcium chelating agent; and by pretreatment with U73,122 (10 muM), a PLC inhibitor, or 2-APB (100 muM), an IP3-receptor antagonist. guanosine 5'-O-(2-thiodiphosphate) inositol 1,4,5-trisphosphate receptor, type 3 Rattus norvegicus