| Protein Name | inositol 1,4,5-trisphosphate receptor, type 3 |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 25679 |
| Gene Symbol | Itpr3 |
| UniProt | Q63269 (ITPR3_RAT), C7E1V1 (C7E1V1_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
116
Total Number of Articles : 147 |
Description |
inositol 1,4,5-trisphosphate receptor, type 3 |
| Gene Summary |
Enables several functions, including alcohol binding activity; identical protein binding activity; and inositol 1,4,5-trisphosphate-gated calcium channel activity. Involved in G protein-coupled receptor signaling pathway; cellular response to cAMP; and positive regulation of cytosolic calcium ion concentration. Located in several cellular components, including apical plasma membrane; brush border; and nuclear outer membrane. Is active in endoplasmic reticulum membrane and presynapse. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease and type 1 diabetes mellitus. Orthologous to human ITPR3 (inositol 1,4,5-trisphosphate receptor type 3). [provided by Alliance of Genome Resources, Jun 2025] |
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| Properties | |