Title : Ursolic acid induces apoptosis in human leukaemia cells and exhibits anti-leukaemic activity in nude mice through the PKB pathway.

Pub. Date : 2012 Mar

PMID : 21950524






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1 In the present study, we investigated the ability of UA to induce apoptosis in human leukaemia cells in relation to its effects on caspase activation, Mcl-1 down-regulation and perturbations in stress-induced signalling pathways such as PKB and JNK. ursolic acid MCL1 apoptosis regulator, BCL2 family member Homo sapiens
2 KEY RESULTS: UA induced apoptosis in human leukaemia cells in a dose- and time-dependent manner; this was associated with caspase activation, down-regulation of Mcl-1 and inactivation of PKB accompanied by activation of JNK. ursolic acid MCL1 apoptosis regulator, BCL2 family member Homo sapiens
3 Enforced activation of PKB by a constitutively active PKB construct prevented UA-mediated JNK activation, Mcl-1 down-regulation, caspase activation and apoptosis. ursolic acid MCL1 apoptosis regulator, BCL2 family member Homo sapiens
4 CONCLUSIONS AND IMPLICATIONS: Collectively, these findings suggest a hierarchical model of UA-induced apoptosis in human leukaemia cells in which UA induces PKB inactivation, leading to JNK activation and culminating in Mcl-1 down-regulation, caspase activation and apoptosis. ursolic acid MCL1 apoptosis regulator, BCL2 family member Homo sapiens
5 CONCLUSIONS AND IMPLICATIONS: Collectively, these findings suggest a hierarchical model of UA-induced apoptosis in human leukaemia cells in which UA induces PKB inactivation, leading to JNK activation and culminating in Mcl-1 down-regulation, caspase activation and apoptosis. ursolic acid MCL1 apoptosis regulator, BCL2 family member Homo sapiens