Pub. Date : 2012 Mar
PMID : 21950524
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | In the present study, we investigated the ability of UA to induce apoptosis in human leukaemia cells in relation to its effects on caspase activation, Mcl-1 down-regulation and perturbations in stress-induced signalling pathways such as PKB and JNK. | ursolic acid | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
2 | KEY RESULTS: UA induced apoptosis in human leukaemia cells in a dose- and time-dependent manner; this was associated with caspase activation, down-regulation of Mcl-1 and inactivation of PKB accompanied by activation of JNK. | ursolic acid | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
3 | Enforced activation of PKB by a constitutively active PKB construct prevented UA-mediated JNK activation, Mcl-1 down-regulation, caspase activation and apoptosis. | ursolic acid | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
4 | CONCLUSIONS AND IMPLICATIONS: Collectively, these findings suggest a hierarchical model of UA-induced apoptosis in human leukaemia cells in which UA induces PKB inactivation, leading to JNK activation and culminating in Mcl-1 down-regulation, caspase activation and apoptosis. | ursolic acid | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
5 | CONCLUSIONS AND IMPLICATIONS: Collectively, these findings suggest a hierarchical model of UA-induced apoptosis in human leukaemia cells in which UA induces PKB inactivation, leading to JNK activation and culminating in Mcl-1 down-regulation, caspase activation and apoptosis. | ursolic acid | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |