Pub. Date : 2011 Oct
PMID : 21947960
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Proteomic analyses of Sirt1-mediated cisplatin resistance in OSCC cell line. | Cisplatin | sirtuin 1 | Homo sapiens |
| 2 | Sirt1, a class III histone deacetylase, was linked to cisplatin resistance in several cancer types; however, the underlying mechanism is still unclear. | Cisplatin | sirtuin 1 | Homo sapiens |
| 3 | Here, we demonstrated that overexpression of Sirt1 survived OSCC cell line Tca8113 under cisplatin treatment. | Cisplatin | sirtuin 1 | Homo sapiens |
| 4 | Notably, BML-210, a chemical inhibitor of class III histone deacetylase, significantly abolished Sirt1-mediated cisplatin resistance in Tca8113 cells. | Cisplatin | sirtuin 1 | Homo sapiens |
| 5 | Further, inactivation of endogenic Sirt1 by nicotinamide markedly increased chemo-sensitivity in cisplatin resistant sub-cell line Tca8113/CDDP. | Cisplatin | sirtuin 1 | Homo sapiens |
| 6 | Further, inactivation of endogenic Sirt1 by nicotinamide markedly increased chemo-sensitivity in cisplatin resistant sub-cell line Tca8113/CDDP. | Cisplatin | sirtuin 1 | Homo sapiens |
| 7 | Finally, we showed that Sirt1 could prevent cisplatin-induced ROS accumulation in Tca8113 cells. | Cisplatin | sirtuin 1 | Homo sapiens |
| 8 | Our findings are considered as a significant step toward a better understanding of Sirt1-mediated cisplatin resistance. | Cisplatin | sirtuin 1 | Homo sapiens |