Pub. Date : 2012 Jan 15
PMID : 21943374
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Iron-mediated retinal degeneration in haemojuvelin-knockout mice. | Iron | hemojuvelin BMP co-receptor | Mus musculus |
| 2 | Haemochromatosis is a genetic disorder of iron overload resulting from loss-of-function mutations in genes coding for the iron-regulatory proteins HFE (human leucocyte antigen-like protein involved in iron homoeostasis), transferrin receptor 2, ferroportin, hepcidin and HJV (haemojuvelin). | Iron | hemojuvelin BMP co-receptor | Mus musculus |
| 3 | Haemochromatosis is a genetic disorder of iron overload resulting from loss-of-function mutations in genes coding for the iron-regulatory proteins HFE (human leucocyte antigen-like protein involved in iron homoeostasis), transferrin receptor 2, ferroportin, hepcidin and HJV (haemojuvelin). | Iron | hemojuvelin BMP co-receptor | Mus musculus |
| 4 | Hjv-/- mice at >=18 months of age had increased iron accumulation in the retina with marked morphological damage compared with age-matched controls; these changes were not found in younger mice. | Iron | hemojuvelin BMP co-receptor | Mus musculus |
| 5 | Taken together, these results confirm the biological importance of HJV in the regulation of iron homoeostasis in the retina and in RPE. | Iron | hemojuvelin BMP co-receptor | Mus musculus |