Title : Impact of genetic polymorphisms of cytochrome P450 2 C (CYP2C) enzymes on the drug metabolism and design of antidiabetics.

Pub. Date : 2011 Nov 15

PMID : 21939641






1 Functional Relationships(s)
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1 In this brief review, we discussed the impact of CYP2C polymorphisms on the metabolic fate of small-molecule antidiabetics including sulfonylureas, meglitinides, thiazolidinediones, gliptins, and gliflozins, with the key drug-protein molecular interactions highlighted. Sulfonylurea Compounds cytochrome P450 family 2 subfamily C member 9 Homo sapiens