Pub. Date : 2011 Sep 21
PMID : 21933441
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | On the possible role of ERK, p38 and CaMKII in the regulation of CGRP expression in morphine-tolerant rats. | Morphine | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 2 | BACKGROUND: The neuropeptide, calcitonin gene-related peptide (CGRP) has been proposed to be a regulator of the development of morphine analgesic tolerance and thereby could be a target to reduce the induction of this phenomenon under clinical conditions. | Morphine | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 3 | BACKGROUND: The neuropeptide, calcitonin gene-related peptide (CGRP) has been proposed to be a regulator of the development of morphine analgesic tolerance and thereby could be a target to reduce the induction of this phenomenon under clinical conditions. | Morphine | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 4 | We investigated here the possible role of the extracellular signal-regulated protein kinase (ERK), p38 and calcium/calmodulin-dependent protein kinase II (CaMKII) in CGRP regulation following chronic morphine treatment. | Morphine | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 5 | RESULTS: A 7-day treatment with morphine (15 mug/day) led to an increase in CGRP contents in the spinal cord dorsal horn (SCDH) and dorsal root ganglion (DRG) and this effect was prevented by the inhibition of the ERK, p38 or CaMKII pathway. | Morphine | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 6 | The blockade of nNOS activity also suppressed chronic morphine-induced CGRP increases in the DRG and SCDH. | Morphine | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 7 | CONCLUSIONS: The activation of spinal ERK, p38 and CaMKII, alongside nNOS, is involved in chronic morphine-induced CGRP up-regulation in both the DRG and SCDH. | Morphine | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 8 | Moreover, the stimulation of CaMKII in the DRG likely directly regulates the expression of CGRP associated with morphine analgesic tolerance. | Morphine | calcitonin-related polypeptide alpha | Rattus norvegicus |