Pub. Date : 2011 Sep 19
PMID : 21929745
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Differential modulatory effects of GSK-3beta and HDM2 on sorafenib-induced AIF nuclear translocation (programmed necrosis) in melanoma. | Sorafenib | MDM2 proto-oncogene | Homo sapiens |
| 2 | The data suggest that the ability of sorafenib to activate GSK-3beta and alter the intracellular distribution of p53 may be exploitable as an adjunct to agents that prevent the HDM2-dependent degradation of p53 in the treatment of melanoma. | Sorafenib | MDM2 proto-oncogene | Homo sapiens |