Title : CITED2 controls the hypoxic signaling by snatching p300 from the two distinct activation domains of HIF-1α.

Pub. Date : 2011 Dec

PMID : 21925214






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 HIF-1alpha induces the expressions of numerous hypoxia-induced genes through two transactivation domains; N-terminal TAD (NAD) and C-terminal TAD (CAD). nadide hypoxia inducible factor 1 subunit alpha Homo sapiens
2 These results indicate that CITED2 inactivates HIF-1alpha by blocking p300 recruitment by both NAD and CAD. nadide hypoxia inducible factor 1 subunit alpha Homo sapiens