Pub. Date : 2011 Jun
PMID : 21924076
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | [Effect of atorvastatin on advanced glycation end products induced monocyte chemoattractant protein-1 expression in cultured human endothelial cells]. | Atorvastatin | C-C motif chemokine ligand 2 | Homo sapiens |
| 2 | OBJECTIVE: To investigate the effects of atorvastatin on advanced glycation end products (AGE) induced monocyte chemoattractant protein-1 (MCP-1) expression in human umbilical vein endothelial cells (HUVECs) and whether this effect could be linked to peroxisome proliferator-activated receptor-gamma (PPAR-gamma) and nuclear factor-kappaB (NF-kappaB). | Atorvastatin | C-C motif chemokine ligand 2 | Homo sapiens |
| 3 | OBJECTIVE: To investigate the effects of atorvastatin on advanced glycation end products (AGE) induced monocyte chemoattractant protein-1 (MCP-1) expression in human umbilical vein endothelial cells (HUVECs) and whether this effect could be linked to peroxisome proliferator-activated receptor-gamma (PPAR-gamma) and nuclear factor-kappaB (NF-kappaB). | Atorvastatin | C-C motif chemokine ligand 2 | Homo sapiens |
| 4 | RESULTS: (1) The expression of MCP-1 mRNA was increased in proportion with increasing concentrations of AGEs which could be blocked by atorvastatin in a dose-dependent manner. | Atorvastatin | C-C motif chemokine ligand 2 | Homo sapiens |
| 5 | (4) PPAR-gamma inhibitor antagonized the effect of atorvastatin on the expression of phospho-NF-kappaB p65 protein, nonphospho-NF-kappaB p65 protein and MCP-1 mRNA stimulated by AGE in HUVECs (P < 0.01). | Atorvastatin | C-C motif chemokine ligand 2 | Homo sapiens |