Pub. Date : 2012 Mar
PMID : 21913896
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effects of atorvastatin metabolites on induction of drug-metabolizing enzymes and membrane transporters through human pregnane X receptor. | Atorvastatin | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |
| 2 | KEY RESULTS: All atorvastatin metabolites induced the assembly of PXR and activated CYP3A4 promoter activity. | Atorvastatin | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |
| 3 | CONCLUSIONS AND IMPLICATIONS: Atorvastatin metabolites are ligands of PXR but not of CAR. | Atorvastatin | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |
| 4 | Atorvastatin metabolites demonstrate differential induction of PXR target genes, which results from impaired release of co-repressors. | Atorvastatin | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |