Pub. Date : 2012 Jan
PMID : 21907283
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Treatment of R6/2 mice with an agonist of PPARgamma (thiazolidinedione, TZD) resulted in a beneficial effect on PPARgamma. | tzd | peroxisome proliferator activated receptor gamma | Mus musculus |
| 2 | Treatment of R6/2 mice with an agonist of PPARgamma (thiazolidinedione, TZD) resulted in a beneficial effect on PPARgamma. | tzd | peroxisome proliferator activated receptor gamma | Mus musculus |
| 3 | By reducing Htt aggregates and thereby ameliorating the recruitment of PPARgamma into Htt aggregates, TZD treatment also elevated the availability of PPARgamma level and subsequently normalized the expression of downstream genes (including PGC-1alpha and several mitochondrial genes) in the cortex. | tzd | peroxisome proliferator activated receptor gamma | Mus musculus |
| 4 | By reducing Htt aggregates and thereby ameliorating the recruitment of PPARgamma into Htt aggregates, TZD treatment also elevated the availability of PPARgamma level and subsequently normalized the expression of downstream genes (including PGC-1alpha and several mitochondrial genes) in the cortex. | tzd | peroxisome proliferator activated receptor gamma | Mus musculus |
| 5 | Our results reveal that TZD and rosiglitazone may play a protective role in HD, and support the view that PPARgamma is a potential therapeutic target in HD. | tzd | peroxisome proliferator activated receptor gamma | Mus musculus |