Title : Distinct regulation of mitogen-activated protein kinase activities is coupled with enhanced cardiac differentiation of human embryonic stem cells.

Pub. Date : 2011 Nov

PMID : 21907163






2 Functional Relationships(s)
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1 Here, we have investigated the enhancing effect of the small molecule SB203580, a p38 MAPK inhibitor, on cardiomyogenesis in hESC by monitoring the phosphorylation patterns of the major MAPK pathway components p38, JNK and ERK by western immunoblotting. SB 203580 mitogen-activated protein kinase 8 Homo sapiens
2 In contrast, moderately elevated SB203580 concentrations (15-30muM) resulted in complete disruption of cardiomyogenesis which was associated with prominent inhibition of ERK and further elevated JNK activity. SB 203580 mitogen-activated protein kinase 8 Homo sapiens