Title : Guggulsterone sensitizes hepatoma cells to TRAIL-induced apoptosis through the induction of CHOP-dependent DR5: involvement of ROS-dependent ER-stress.

Pub. Date : 2011 Dec 1

PMID : 21903093






1 Functional Relationships(s)
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1 Pretreatment with N-acetyl-L-cysteine and glutathione inhibited GGS-induced ER-stress, and CHOP and DR5 upregulation and almost completely blocked GGS/TRAIL-induced apoptosis. Acetylcysteine DNA damage inducible transcript 3 Homo sapiens