Title : The combination of BH3-mimetic ABT-737 with the alkylating agent temozolomide induces strong synergistic killing of melanoma cells independent of p53.

Pub. Date : 2011

PMID : 21897876






3 Functional Relationships(s)
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1 We found that TMZ treatment elevated p53 levels, and that the pro-apoptotic protein Noxa was elevated in TMZ/ABT-737 treated cells. ABT-737 phorbol-12-myristate-13-acetate-induced protein 1 Homo sapiens
2 Experiments with shRNA demonstrated that the synergistic effect of TMZ and ABT-737 was largely dependent on Noxa. ABT-737 phorbol-12-myristate-13-acetate-induced protein 1 Homo sapiens
3 Experiments with nutlin-3, a p53 inducer, demonstrated that p53 induction was sufficient for synergistic cell death with ABT-737 in a Noxa-dependent fashion. ABT-737 phorbol-12-myristate-13-acetate-induced protein 1 Homo sapiens