Title : Discovery of gemfibrozil analogues that activate PPARĪ± and enhance the expression of gene CPT1A involved in fatty acids catabolism.

Pub. Date : 2011 Oct

PMID : 21889235






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1 Discovery of gemfibrozil analogues that activate PPARalpha and enhance the expression of gene CPT1A involved in fatty acids catabolism. Gemfibrozil peroxisome proliferator activated receptor alpha Homo sapiens
2 A new series of gemfibrozil analogues conjugated with alpha-asarone, trans-stilbene, chalcone, and their bioisosteric modifications were synthesized and evaluated to develop PPARalpha agonists. Gemfibrozil peroxisome proliferator activated receptor alpha Homo sapiens