Title : Trastuzumab enhances the anti-tumor effects of the histone deacetylase inhibitor sodium butyrate on a HER2-overexpressing breast cancer cell line.

Pub. Date : 2011 Dec

PMID : 21887460






2 Functional Relationships(s)
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1 To elucidate whether combined treatment with NaB and trastuzumab exerts anti-tumor effects on a HER2-overexpressing breast cancer cell line, SKBR3 cells were treated with NaB alone or in combination with trastuzumab, and the effects on proliferation and cell cycle progression were analyzed. nab erb-b2 receptor tyrosine kinase 2 Homo sapiens
2 In conclusion, trastuzumab significantly improved the antitumor effect of NaB on HER2-overexpressing breast cancer cell line in vitro. nab erb-b2 receptor tyrosine kinase 2 Homo sapiens