Pub. Date : 2012 Oct
PMID : 21884024
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The aim of this review is to provide useful information not only for studying the effect of OATP1B1 and/or BCRP gene mutation on pharmacokinetics of novle statins of pitavastatin and rosuvastatin but also for studying drug-drug interactions (DDI) between the novle statins and other substrates of OATP1B1 and/or BCRP. | pitavastatin | solute carrier organic anion transporter family member 1B1 | Homo sapiens |
| 2 | In this presentation, we introduce single nucleotide polymorphisms (SNPs) of OATP1B1 and BCRP and review the contribution of genetic polymorphisms of the transporters to the pharmacokinetics of dual substrates as pitavastatin and rosuvastatin from recent study. | pitavastatin | solute carrier organic anion transporter family member 1B1 | Homo sapiens |
| 3 | At the same time, the DDIs between pitavastatin or rosuvastatin and other drug have been extensively concerned because of inhibiting OATP1B1-mediated hepatic uptake or BCRP-mediated hepatic efflux of pitavastatin and rosuvastatin. | pitavastatin | solute carrier organic anion transporter family member 1B1 | Homo sapiens |
| 4 | This review summarized the current studies about the role of OATP1B1 and BCRP in DDIs between pitavastatin or rosuvastatin and other clinically relevant drugs. | pitavastatin | solute carrier organic anion transporter family member 1B1 | Homo sapiens |
| 5 | The role of OATP1B1 and BCRP gene mutation can affect the PK profiles of pitavastatin and rosuvastatin. | pitavastatin | solute carrier organic anion transporter family member 1B1 | Homo sapiens |