Title : The mammalian target of rapamycin regulates cholesterol biosynthetic gene expression and exhibits a rapamycin-resistant transcriptional profile.

Pub. Date : 2011 Sep 13

PMID : 21876130






1 Functional Relationships(s)
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1 We show that the ATP-competitive inhibitor PP242, but not rapamycin, significantly down-regulates cholesterol biosynthesis genes in a 4E-BP1-dependent manner in NIH 3T3 cells, whereas S6 kinase 1 is the dominant regulator in hepatocellular carcinoma cells. PP242 eukaryotic translation initiation factor 4E binding protein 1 Mus musculus