Title : Beta1 integrin cytoplasmic tyrosines promote skin tumorigenesis independent of their phosphorylation.

Pub. Date : 2011 Sep 13

PMID : 21876123






2 Functional Relationships(s)
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1 We found that hydrophobic phenylalanine substitutions of both tyrosines diminished the binding of tail-interacting proteins, including talins and kindlins, resulting in reduced beta1-mediated adhesion, focal adhesion kinase (FAK) signaling, and epidermal progenitor cell-derived skin tumors. Tyrosine PTK2 protein tyrosine kinase 2 Mus musculus
2 We found that hydrophobic phenylalanine substitutions of both tyrosines diminished the binding of tail-interacting proteins, including talins and kindlins, resulting in reduced beta1-mediated adhesion, focal adhesion kinase (FAK) signaling, and epidermal progenitor cell-derived skin tumors. Tyrosine PTK2 protein tyrosine kinase 2 Mus musculus