Pub. Date : 2011 Dec
PMID : 21872646
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Synergistic inhibition of butyrylcholinesterase by galantamine and citalopram. | Galantamine | butyrylcholinesterase | Homo sapiens |
| 2 | RESULTS: Galantamine almost completely inhibited BuChE at low substrate concentrations (V(S)=43.6 muM/min; V(S(gal))=0.34 muM/min) without influencing the substrate-activated form of the enzyme (V(SS)=64.0 muM/min;V(SS(gal))=62.3 muM/min). | Galantamine | butyrylcholinesterase | Homo sapiens |
| 3 | CONCLUSION: Citalopram and galantamine produce a combined inhibition of BuChE that is considered to be synergistic. | Galantamine | butyrylcholinesterase | Homo sapiens |
| 4 | GENERAL SIGNIFICANCE: Clinical benefit from combined galantamine and citalopram may be related to a synergistic inhibition of BuChE, facilitating cholinergic neurotransmission. | Galantamine | butyrylcholinesterase | Homo sapiens |