Pub. Date : 2011 Oct 1
PMID : 21868755
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Celecoxib promotes c-FLIP degradation through Akt-independent inhibition of GSK3. | Celecoxib | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | We found that celecoxib controlled c-FLIP ubiquitination through Akt-independent inhibition of glycogen synthase kinase-3 (GSK3), itself a candidate therapeutic target of interest in colon cancer. | Celecoxib | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Celecoxib increased the levels of phosphorylated GSK3, including the alpha and beta forms, even in cell lines, where phosphorylated Akt levels were not increased. | Celecoxib | AKT serine/threonine kinase 1 | Homo sapiens |