Title : cGMP inhibits TGF-beta signaling by sequestering Smad3 with cytosolic beta2-tubulin in pulmonary artery smooth muscle cells.

Pub. Date : 2011 Oct

PMID : 21868450






1 Functional Relationships(s)
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1 In contrast, the microtubule stabilizers paclitaxel and epothilone B increased cytosolic Smad3 binding to beta2-tubulin and enhanced the inhibitory effect of cGMP on Smad3 nuclear translocation and PAI-1 expression in response to TGF-beta1. epothilone B serpin family E member 1 Homo sapiens