Pub. Date : 2011 Sep 1
PMID : 21862872
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Potent anti-proliferative effects of metformin on trastuzumab-resistant breast cancer cells via inhibition of erbB2/IGF-1 receptor interactions. | Metformin | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 2 | We have shown that erbB2 altered breast cancer cells are less sensitive to the anti-proliferative effects of metformin than triple negative cells, and have described the differences of molecular mechanisms of metformin action by tumor subtypes. | Metformin | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 3 | We have shown that erbB2 altered breast cancer cells are less sensitive to the anti-proliferative effects of metformin than triple negative cells, and have described the differences of molecular mechanisms of metformin action by tumor subtypes. | Metformin | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 4 | We hypothesized that metformin may be more effective against trastuzumab-resistant erbB2-overexpressing breast cancer cells because it targets the critical signaling pathways that are altered with resistance. | Metformin | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 5 | Metformin disrupts erbB2/IGF-1R complexes, erbB3 and IGF-1R expression and activity, as well as Src kinase and/or PI-3K/Akt signaling. | Metformin | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 6 | Our findings provide a rationale to study the effects of metformin on patients with erbB2 positive tumors treated with trastuzumab, with or without resistance. | Metformin | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |