Title : [Effects of inorganic arsenic on mRNA expression of Nrf2 and Nrf2-regulated downstream anti-oxidant enzymes in Chang hepatocytes].

Pub. Date : 2011 Jul

PMID : 21861350






2 Functional Relationships(s)
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1 METHODS: Chang hepatocytes were treated with 5, 10, 25 and 50 micromol/L of sodium arsenite (NaAsO2) for 6h, and RT-PCR were then performed to detect the mRNA expression of Nrf2, NQO1 and HO-1. sodium arsenite NFE2 like bZIP transcription factor 2 Homo sapiens
2 RESULTS: When exposed to 5, 10, 25 and 50 micromol/L of NaAsO2, Nrf2 mRNA were (100.74 +/- 3.70)%, (105.96 +/- 1.75)%, (101.76 +/- 1.01)% and (101.81 +/- 6.33)% of control,showing no statistic significance (P > 0.05). sodium arsenite NFE2 like bZIP transcription factor 2 Homo sapiens