Title : Combination of midazolam and a cyclooxygenase-2 inhibitor inhibits lipopolysaccharide-induced interleukin-6 production in human peripheral blood mononuclear cells.

Pub. Date : 2012 Feb

PMID : 21854184






5 Functional Relationships(s)
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1 Combination of midazolam and a cyclooxygenase-2 inhibitor inhibits lipopolysaccharide-induced interleukin-6 production in human peripheral blood mononuclear cells. Midazolam interleukin 6 Homo sapiens
2 Midazolam has been reported to modulate IL-6 response. Midazolam interleukin 6 Homo sapiens
3 OBJECTIVE: The aim of the present study was to evaluate the effect of the combination of midazolam and a COX inhibitor on IL-6 production. Midazolam interleukin 6 Homo sapiens
4 DISSCUSSION AND CONCLUSION: The results in the present study demonstrated that the combination of midazolam and a COX-2 inhibitor inhibited LPS-induced IL-6 production in human PBMCs even if each drug separately did not have any effect on it. Midazolam interleukin 6 Homo sapiens
5 The finding suggests that their combination is effective against excessive IL-6 production such as severe inflammatory response and that the effect of midazolam on IL-6 production is possibly elicited via 15dPGJ2. Midazolam interleukin 6 Homo sapiens