Pub. Date : 2011 Oct 3
PMID : 21851097
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here we used novel strategies to target microsomal glutathione transferase 1 (MGST1) and glutathione transferase pi (GSTP) that are often overexpressed in tumors and confer resistance against a number of cytostatic drugs, including cisplatin and doxorubicin (DOX). | Doxorubicin | microsomal glutathione S-transferase 1 | Homo sapiens |
| 2 | Here we used novel strategies to target microsomal glutathione transferase 1 (MGST1) and glutathione transferase pi (GSTP) that are often overexpressed in tumors and confer resistance against a number of cytostatic drugs, including cisplatin and doxorubicin (DOX). | Doxorubicin | microsomal glutathione S-transferase 1 | Homo sapiens |
| 3 | Here we synthesized two derivatives of DOX, 2,4-dinitrobenzenesulfonyl doxorubicin (DNS-DOX) and 4-mononitrobenzenesulfonyl doxorubicin (MNS-DOX) and showed that they are substrates for MGST1 and GSTP (releasing DOX). | Doxorubicin | microsomal glutathione S-transferase 1 | Homo sapiens |
| 4 | MGST1 overexpressing cells are resistant to DOX. | Doxorubicin | microsomal glutathione S-transferase 1 | Homo sapiens |
| 5 | It would appear that, by controlling the reactivity of the prodrug, and thereby the DOX release rate, selective toxicity to MGST1 overexpressing cells can be achieved. | Doxorubicin | microsomal glutathione S-transferase 1 | Homo sapiens |