Title : Syntheses of mGluR5 PET radioligands through the radiofluorination of diaryliodonium tosylates.

Pub. Date : 2011 Oct 7

PMID : 21845279






1 Functional Relationships(s)
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1 3-Fluoro-1-((thiazol-4-yl)ethynyl)benzenes constitute an important class of high-affinity metabotropic glutamate subtype 5 receptor (mGluR5) ligands, some of which have been labeled with fluorine-18 (t(1/2) = 109.7 min), to provide radioligands for molecular imaging of brain mGluR5 in living animal and human subjects with positron emission tomography (PET). Fluorine-18 glutamate receptor, ionotropic, kainate 1 Mus musculus