Title : MNU-induced mammary gland carcinogenesis: chemopreventive and therapeutic effects of vitamin D and Seocalcitol on selected regulatory vitamin D receptor pathways.

Pub. Date : 2011 Nov 10

PMID : 21843606






3 Functional Relationships(s)
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1 Using PET analysis, reduction in [18F]2-fluoro-2-deoxy-d-glucose (FDG) uptake or tumor volume in tumors chemopreventively treated with vitamin D3 were detected in MNU-induced tumors, vitamin D3 reduced expression of 25-hydroxylase (25OHase) (p<0.01) and 24-hydroxylase (24OHase) (p<0.01) and Seocalcitol 24OHase. Cholecalciferol cytochrome P450, family 24, subfamily a, polypeptide 1 Rattus norvegicus
2 Using PET analysis, reduction in [18F]2-fluoro-2-deoxy-d-glucose (FDG) uptake or tumor volume in tumors chemopreventively treated with vitamin D3 were detected in MNU-induced tumors, vitamin D3 reduced expression of 25-hydroxylase (25OHase) (p<0.01) and 24-hydroxylase (24OHase) (p<0.01) and Seocalcitol 24OHase. Cholecalciferol cytochrome P450, family 24, subfamily a, polypeptide 1 Rattus norvegicus
3 Positive regulation of 25OHase mRNA level after the treatment with vitamin D3 was observed in liver, while in kidney, vitamin D3 and Seocalcitol induced expression of 24OHase was significant. Cholecalciferol cytochrome P450, family 24, subfamily a, polypeptide 1 Rattus norvegicus