Title : Activation of Akt/GSK3β and Akt/Bcl-2 signaling pathways in nickel-transformed BEAS-2B cells.

Pub. Date : 2011 Nov

PMID : 21837363






1 Functional Relationships(s)
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1 Taken together, these findings demonstrate that activation of Akt, followed by GSK3beta inhibition and Bcl-2, Bcl-XL up-regulation and decrease of ROS generation, along with a synergistic effect of Rb down-regulation may cause apoptosis resistance, contributing to the overall mechanism of nickel carcinogenesis. ros AKT serine/threonine kinase 1 Homo sapiens