PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21837363-12 2011 Taken together, these findings demonstrate that activation of Akt, followed by GSK3beta inhibition and Bcl-2, Bcl-XL up-regulation and decrease of ROS generation, along with a synergistic effect of Rb down-regulation may cause apoptosis resistance, contributing to the overall mechanism of nickel carcinogenesis. ros 147-150 AKT serine/threonine kinase 1 Homo sapiens 62-65