Pub. Date : 2012 Jan
PMID : 21835258
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The COX-2 inhibitor Celecoxib enhances the sensitivity of KB/VCR oral cancer cell lines to Vincristine by down-regulating P-glycoprotein expression and function. | Celecoxib | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | Using the MTT method, we investigated the influence of the COX-2 selective inhibitor Celecoxib on the proliferation of KB/VCR oral cancer cell lines and analyzed the effect of Celecoxib on the regulation of P-glycoprotein (P-gp) expression and function. | Celecoxib | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | P-gp expression levels in KB/KBV cells treated with Celecoxib plus VCR (10 mumol/L+1.5 mumol/L, respectively) were markedly lower than the levels in control cells and those treated with VCR (1.5 mumol/L) (all P<0.01). | Celecoxib | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | The underlying mechanism of these phenomena is likely correlated with the down-regulation of the expression and function of P-gp due to Celecoxib, thereby increasing the amount of VCR accumulated in KB/VCR cells. | Celecoxib | ATP binding cassette subfamily B member 1 | Homo sapiens |