Title : The clozapine metabolite N-desmethylclozapine displays variable activity in diverse functional assays at human dopamine D₂ and serotonin 5-HT₁A receptors.

Pub. Date : 2011 Nov 1

PMID : 21835172






1 Functional Relationships(s)
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1 In contrast, there were weak partial agonist actions of NDMC (but not of clozapine) for dopamine D(2)-dependent activation of Ca(2+) liberation via coexpressed chimeric Galpha(q/o) proteins and for G protein-coupled inward rectifier potassium channel (GIRK) current induction in Xenopus oocytes. Dopamine potassium inwardly rectifying channel subfamily J member 3 S homeolog Xenopus laevis