Title : Cyclo-oxygenase-2 knockout genotype in mice is associated with blunted angiotensin II-induced oxidative stress and hypertension.

Pub. Date : 2011 Nov

PMID : 21833043






2 Functional Relationships(s)
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1 RESULTS: At resting state, the superoxide production in aortic and cardiac tissues was lower in cyclo-oxygenase-2 deficient than in the wild type or in cyclo-oxygenase-1 deficient mice. Superoxides prostaglandin-endoperoxide synthase 2 Mus musculus
2 CONCLUSIONS: Cyclo-oxygenase-2 pathway plays a major role in the superoxide generation as well as in the angiotensin II-induced oxidative stress and blood pressure. Superoxides prostaglandin-endoperoxide synthase 2 Mus musculus