Title : Luciferin IPA-based higher throughput human hepatocyte screening assays for CYP3A4 inhibition and induction.

Pub. Date : 2011 Sep

PMID : 21832258






1 Functional Relationships(s)
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1 In the 384-well plate CYP3A4 inhibition assay, the known inhibitors 1-aminobenzotriazole, erythromycin, ketoconazole, and verapamil were found to cause extensive (maximum inhibition of >80%), dose-dependent, statistically significant inhibition of LIPA metabolism. Verapamil cytochrome P450 family 3 subfamily A member 4 Homo sapiens