Pub. Date : 2011 Sep 30
PMID : 21832094
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Importantly, desipramine belongs to a group of tricyclic antidepressant compounds that can simultaneously block hERG and inhibit its surface expression. | Desipramine | ETS transcription factor ERG | Homo sapiens |
| 2 | Here, we have studied in detail how desipramine inhibits hERG surface expression. | Desipramine | ETS transcription factor ERG | Homo sapiens |
| 3 | We find a previously unrecognized combination of two entirely different mechanisms; desipramine increases hERG endocytosis and degradation as a consequence of drug-induced channel ubiquitination and simultaneously inhibits hERG forward trafficking from the endoplasmic reticulum. | Desipramine | ETS transcription factor ERG | Homo sapiens |
| 4 | We find a previously unrecognized combination of two entirely different mechanisms; desipramine increases hERG endocytosis and degradation as a consequence of drug-induced channel ubiquitination and simultaneously inhibits hERG forward trafficking from the endoplasmic reticulum. | Desipramine | ETS transcription factor ERG | Homo sapiens |