Title : Hypocretin/orexin signaling in the hypothalamic paraventricular nucleus is essential for the expression of nicotine withdrawal.

Pub. Date : 2012 Feb 1

PMID : 21831361






2 Functional Relationships(s)
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1 Nicotine withdrawal increased the percentage of hypocretin cells expressing c-Fos in the perifornical, dorsomedial, and lateral hypothalamus. Nicotine hypocretin Mus musculus
2 CONCLUSIONS: These data demonstrate that hypocretin signaling acting on Hcrtr-1 in the PVN plays a crucial role in the expression of nicotine withdrawal. Nicotine hypocretin Mus musculus