Title : Attenuation of ERK/RSK2-driven NFκB gene expression and cancer cell proliferation by kurarinone, a lavandulyl flavanone isolated from Sophora flavescens ait. roots.

Pub. Date : 2011 Sep 1

PMID : 21831037






2 Functional Relationships(s)
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1 Attenuation of ERK/RSK2-driven NFkappaB gene expression and cancer cell proliferation by kurarinone, a lavandulyl flavanone isolated from Sophora flavescens ait. kurarinone ribosomal protein S6 kinase A3 Homo sapiens
2 Our results in estrogen-unresponsive fibroblasts, ribosomal S6 kinase 2 kinase (RSK2) knockout cells, and estrogen receptor (ER)-deficient breast tumor cells show that kurarinone can inhibit tumor cell proliferation and selectively block nuclear NFkappaB transactivation of specific target genes such as IL6, cyclin D1, SOD2 but not TNFAIP2. kurarinone ribosomal protein S6 kinase A3 Homo sapiens