Pub. Date : 2012 Jan
PMID : 21818627
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Akt and NF-kappaB related inflammatory cytokine IL-1alpha, and IL-6 and the chemokine IL-8 were upregulated in treated cells at 6 and 24 h. The calpain inhibitor leupeptin limited Akt phosphorylation to Ser(473) and reduced release of IL-1alpha, IL-6, and IL-8, indicating that calpain or similar protease(s) are involved in PM-induced activation of Akt and subsequent release of inflammatory cytokines. | Serine | nuclear factor kappa B subunit 1 | Homo sapiens |