Title : Aspirin extrusion from human platelets through multidrug resistance protein-4-mediated transport: evidence of a reduced drug action in patients after coronary artery bypass grafting.

Pub. Date : 2011 Aug 9

PMID : 21816313






1 Functional Relationships(s)
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1 RESULTS: Inhibition of MRP4-mediated transport by dipyridamole or Mk-571 increases aspirin entrapment and its in vitro effect on COX-1 activity (142.7 +- 34.6 pg/10(8) cells vs. 343.7 +- 169.3 pg/108 cells TxB2-production). Dipyridamole ATP binding cassette subfamily C member 4 Homo sapiens