Pub. Date : 2011 Sep 21
PMID : 21813412
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The role of p27(Kip1) in dasatinib-enhanced paclitaxel cytotoxicity in human ovarian cancer cells. | Paclitaxel | cyclin dependent kinase inhibitor 1B | Homo sapiens |
| 2 | The siRNA knockdown of p27(Kip1) decreased dasatinib- and paclitaxel-induced apoptosis compared with a negative control siRNA (sub-G1 fraction, control siRNA vs. p27(Kip1) siRNA: 42.5% vs. 20.1%, difference = 22.4%, 95% CI = 20.1% to 24.7%, P = .017). | Paclitaxel | cyclin dependent kinase inhibitor 1B | Homo sapiens |
| 3 | Studies with forced expression and siRNA knockdown of Bcl-2 and Cdk1 suggest that dasatinib-mediated induction of p27(Kip1) enhanced paclitaxel-induced apoptosis by negatively regulating Bcl-2 and Cdk1 expression. | Paclitaxel | cyclin dependent kinase inhibitor 1B | Homo sapiens |
| 4 | CONCLUSION: Inhibition of Src family and Abl kinases with either siRNAs or dasatinib enhances paclitaxel sensitivity of ovarian cancer cells through p27(Kip1)-mediated suppression of Bcl-2 and Cdk1 expression. | Paclitaxel | cyclin dependent kinase inhibitor 1B | Homo sapiens |