Title : Inhibition of inflammation by pentosan polysulfate impedes the development and progression of severe diabetic nephropathy in aging C57B6 mice.

Pub. Date : 2011 Oct

PMID : 21808238






3 Functional Relationships(s)
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1 PPS also reduced upregulation of TNFalpha and proinflammatory genes in aging diabetic kidneys. Pentosan Sulfuric Polyester tumor necrosis factor Mus musculus
2 Furthermore, PPS suppressed NF-kappaB, decreased the proinflammatory actions of TNFalpha, and decreased high glucose and AGEs stimulated MCP-1 production in vitro. Pentosan Sulfuric Polyester tumor necrosis factor Mus musculus
3 Finally, PPS decreased TNFalpha-induced increase in albumin permeability in podocyte monolayers. Pentosan Sulfuric Polyester tumor necrosis factor Mus musculus