Title : Orthovanadate-induced cell death in RET/PTC1-harboring cancer cells involves the activation of caspases and altered signaling through PI3K/Akt/mTOR.

Pub. Date : 2011 Sep 12

PMID : 21807000






1 Functional Relationships(s)
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1 In contrast, treatment with inhibitory concentrations of orthovanadate results in increased phosphorylation of tyrosine 451 of RET/PTC1 and activation of the mTOR/S6R branch of the PI3K/Akt signaling pathway. Tyrosine ret proto-oncogene Homo sapiens