Title : Structure-guided design and synthesis of P1' position 1-phenylcycloalkylamine-derived pentapeptidic BACE1 inhibitors.

Pub. Date : 2011 Sep 1

PMID : 21803585






1 Functional Relationships(s)
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1 Previously, we reported potent pentapeptidic BACE1 inhibitors with the hydroxymethylcarbonyl isostere as a substrate transition-state mimic. isostere beta-secretase 1 Homo sapiens