Title : Synergy between TLR3 and IL-18 promotes IFN-γ dependent TRAIL expression in human liver NK cells.

Pub. Date : 2011

PMID : 21802664






4 Functional Relationships(s)
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1 Our results show that the synthetic dsRNA polyinosinic-polycytidylic acid (poly I:C), a mimic of a common product of viral infections, activates NK cells directly in the context of cytokines found in the liver, i.e.: poly I:C plus inflammatory cytokines (IL-18, IL-12, and IL-2) induced NK cell IFN-gamma production and TRAIL expression, and anti-inflammatory cytokines (TGF-beta and IL-10) inhibit NK cell IFN-gamma production. Poly I-C interferon gamma Homo sapiens
2 Our results show that the synthetic dsRNA polyinosinic-polycytidylic acid (poly I:C), a mimic of a common product of viral infections, activates NK cells directly in the context of cytokines found in the liver, i.e.: poly I:C plus inflammatory cytokines (IL-18, IL-12, and IL-2) induced NK cell IFN-gamma production and TRAIL expression, and anti-inflammatory cytokines (TGF-beta and IL-10) inhibit NK cell IFN-gamma production. Poly I-C interferon gamma Homo sapiens
3 Our results show that the synthetic dsRNA polyinosinic-polycytidylic acid (poly I:C), a mimic of a common product of viral infections, activates NK cells directly in the context of cytokines found in the liver, i.e.: poly I:C plus inflammatory cytokines (IL-18, IL-12, and IL-2) induced NK cell IFN-gamma production and TRAIL expression, and anti-inflammatory cytokines (TGF-beta and IL-10) inhibit NK cell IFN-gamma production. Poly I-C interferon gamma Homo sapiens
4 Our results show that the synthetic dsRNA polyinosinic-polycytidylic acid (poly I:C), a mimic of a common product of viral infections, activates NK cells directly in the context of cytokines found in the liver, i.e.: poly I:C plus inflammatory cytokines (IL-18, IL-12, and IL-2) induced NK cell IFN-gamma production and TRAIL expression, and anti-inflammatory cytokines (TGF-beta and IL-10) inhibit NK cell IFN-gamma production. Poly I-C interferon gamma Homo sapiens