Pub. Date : 2011 Oct 28
PMID : 21801798
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The aromatic volatile organic compounds toluene, benzene and styrene induce COX-2 and prostaglandins in human lung epithelial cells via oxidative stress and p38 MAPK activation. | Benzene | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 2 | In addition, we studied the potential role of oxidative stress and p38 MAPK activation in the toluene/benzene/styrene-dependent COX-2 induction. | Benzene | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 3 | Treatment of the cells with a specific p38 inhibitor (SB203580) or the antioxidant N-acetylcysteine (NAC) was able to prevent the toluene/benzene/styrene-dependent COX-2 activation, and subsequent increased PGE(2) and PGF(2alpha) secretion. | Benzene | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 4 | These results suggest that toluene, benzene and styrene induce production and secretion of PGE(2) and PGF(2alpha) in lung epithelial cells via p38 MAPK and COX-2 activation in a redox sensitive manner. | Benzene | prostaglandin-endoperoxide synthase 2 | Homo sapiens |